Sinatra Syndrome

“And now, the end is near, and so I face the final curtain

My friend, I’ll say it clear, I’ll state my case, of which I’m certain

I’ve lived a life that’s full, I’ve travelled each and every highway

and more, much more than this, I did it my way.”

First verse of “My Way” music: Claude Francois and Jacques Revaux - lyrics: Paul AnkaSecond most covered song in history after “Yesterday”-The Beatles-Paul McCartney

The code for doing things “My Way” in every cell in any organism is contained in the DNA. The actual doing, the acting, the making, the action component during cell life is RNA. DNA lies in its mass of chromatin goo inside the cell nucleus,  like a partially gutted fat worm while RNA does most of the work outside the nuclear membrane in the cytoplasm.  DNA is the deep brains of the outfit doing things “My Way”

Sinatra Syndrome:  A condition of annoyance at confusion observed in other scientists who do not see the matter “My Way”

Examples:

1. Stephen Jay Gould railing against dogma-bound neo darwinists who fail to acknowledge the obvious phenomenon of punctuated equilibrium so clearly visible in the work of Gould and his colleague Niles Eldredge. Gould’s point is that Darwin’s idea that species evolve gradually over vast eons does not hold up in light of lots of evidence to the contrary.
2. Lynn Margulis railing against these same neo darwinists who failed for many years to acknowledge the fact of speciation by symbiosis rather than genetic mutation-natural selection as Central Dogmatists would have it using Mendel and Watson-Crick to flesh out the Darwin theory of evolution. Professor Margulis’ idea of symbiosis also covers the idea of cell complexity resulting from symbiosis rather than genetic mutation using the unique genetics of each cell’s mitochondria that is distinct from the nuclear genome of an animal cell.

“Positivism asserts that all authentic knowledge allows verification and that all authentic knowledge assumes that the only valid knowledge is scientific.” - Auguste Comte

Positivism-Key Features:

1. A focus on science as a product, a linguistic or numerical set of statements.
2. A concern with axiomatization, that is, with demonstrating the logical structure and coherence of these statements.
3. An insistence on at least some of these statements being testable, amenable to being verified, confirmed or shown to be false by the empirical observation of reality.
4. The belief that science is cumulative
5. The belief that science is trans-cultural
6. The belief that science is not associated with personality or social position of the investigator.
7. The belief that science may incorporate new ideas discontinuous from old ones.
8. The belief in the unity of science, that underlying various disciplines, there is one science about the real world.
9. The belief that science is nature and nature is science and out of this duality all theories and postulates are created, interpreted, evolve and are applied.
10. The belief that all things are ultimately measurable.
11. The belief that entities of one kind are reducible to entities of another: societies to individuals, mental events to neural phenomena.
12. The belief that processes are reducible to physiological, physical, or chemical events.
13. The belief that social processes are reducible to relationships between and actions of individuals.
14. The belief that biological organisms are reducible to physical systems.
15. The belief that natural science and social science are members of the same genre.

Our social order gave the medical profession power over the mentally ill in the early 19th century when a medical certificate became mandatory for confinement. No one ever relinquishes power, it must be torn away by revolution or dissolved by humiliation.

RE: French Postmodern philosophy - Debord’s “Spectacle” Deleuze and Guattari’s “Rhizomatic Network” Baudrillard’s “Simulacrum” are the same thing. The weltanschauung-zeitgeist of our contemporary culture of the commodity.

The human neocortex is a personal device used to tap into an array of cultural programs prepared by history; programs of language, religion, philosophy, kinship, science, art, law, etc. The neocortex also has a little-used capacity to feedback into these programmed systems and change them. You get brainwashed by movies but you can also write a screenplay. The culture needs more from you than your purchasing pattern and your daily use of public utilities and infrastructure. You signify in the culture by default by your physical presence but you can also signify by launching a social-political revolution.

The combined complexity of all 20th, 21st technology from microprocessors to jet engines and mars landers amounts to one billionth the sophistication of a single one of a million species of invisible bacteria. We think we are such hot stuff and that we are smart enough to continue to poison the planet and get away with it. The stinkiest bacterium outshines all human creations by a power of 7.

Questions:

1. Is the RNA at the ribosomes in kupffer cells ( at liver) identical throughout 1,000 ribosomes in a single kupffer cells?
2. Does the RNA-eome ( genome, proteome) at ribosomes in hepatocytes correlate to the proteins made in this cell type?
3. Are there 500 different types of RNA in the mammal liver one for each of 500 liver functions?  Are there 500 varieties of ribosome in the liver or do ribosomes perform multiple duties?
4. Does messenger RNA copy exactly - base for base at nucleotide string at separated DNA strand in the nucleus or does it record the opposite nucleotide? i.e. A to A or is it A to T?
5. Do nuclear pores open and close to allow passage of tRNA or are these pores always open i.e. the same diameter?
6. At what point in embryo development does RNA begin its work of cell-specific synthesis? The hepatocytes in the developing liver specifically.
7. Is RNA carried separately from DNA in sperm at fertilization?  Yes, there are thousands of types of RNA in the sperm outside of the paternal haplotype sperm chromosomes at fertilization that carry a wide array of genetic information into the new life independent of DNA or even epigenetically modified DNA.
8. Perhaps the methylation of uracil at RNA forms TTT memory ( traumatic transmission of bad memories across generations as at Holocaust survivor to child) and this methylated RNA is inherited transgenerationally.

One of the great ironies of the 20th century was JFK’s great speechwriter Ted Sorensen writing the eulogy delivered by JFK’s purported assassination conspirator LBJ at JFK’s funeral.  Smooth transition indeed. Did either JFK or LBJ do “it” their way?

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10-3-15  5:45pm